PHYS30001 Lecture Notes - Lecture 32: Hypertrophy, Birth Weight, Impaired Glucose Tolerance
Document Summary
Hypertrophy at much younger age, changed renal function. F1 growth restricted females develop adverse pregnancy adaptations which may influence f2 fetal growth & transgenerational disease development. Pregnancy is a 2nd hit: women who are susceptible to disease risk because they were born small have increased risk due to mal-adaptations - impact on next generation. F2 nephron number was reduced (-15-22%) in f2 restricted males and females at e20 but restored at post-natal pn35. Transmission of f2 fetal nephron deficit not sustained postnatally suggesting delayed nephrogenesis. Development did not occur in normal trajectory - impact later in life. F2 cardiovascular and renal function: transgenerational transmission of f2 high blood pressure. F2 metabolic function: (group = restricted vs control) F2 first phase insulin secretion in f2 6m males and females born to growth restricted. F2 -cell mass in males but nearly compensatory -cell mass in females - maybe this gives them gender protection.
