PHYS30001 Lecture Notes - Lecture 34: Vascular Endothelial Growth Factor, Pre-Eclampsia, Angiogenesis
Document Summary
, greatly increased; , increased; , decreased; --, no change, relative to nonpregnant. Increase in serum sflt is correlated with a decrease in serum vascular endothelial growth factor (vegf) There is a balance between sflt and vegf (angiogenesis, vascular relaxation) in circulation. During preg, vegf levels increase, but in preeclampsia the balance is shifted. sflt binds to vegf, so it cannot act on its receptors to produce normal angiogenesis and. Cardio page 5 sflt binds to vegf, so it cannot act on its receptors to produce normal angiogenesis and relaxation. Treatment of pregnant rats with an sflt-1 adenovirus. Treatment with sflt-1 increased map and caused proteinuria. Mimics pe, confirms that sflt is the cause. Decreased ability of renal microvessels to dilate. sflt causes endothelial dysfunction. V+ and p+ represent responses to vegf and plgf in the presence of sflt1 at 100 ng/ml. A positive change reflects an increase in vessel diameter.
