PHYS30001 Lecture Notes - Lecture 32: Adipose Tissue, Confounding, Beta Cell
Document Summary
Obese women ( risk): gestational hypertension, diabetes & preeclampsia. Individuals born small are predisposed to developing obesity. F1 maternal dorsal fat (don"t need to know graph details, just take home message) F1 maternal high fat diet body weight, in both normal weight and those born. F1 maternal dorsal fat weight in control and restricted mothers, and exercise dorsal fat gain in high fat fed mothers small. High fat diet exacerbated glucose intolerance in restricted (mothers born small) - pushes her towards gestational diabetes phenotype. Control (mothers born normal weight) don"t have glucose intolerance on chow; high fat diet gives them glucose intolerance. Exercise (prior/during pregnancy) prevented glucose intolerance by -cell mass, in both control/restricted. Consumption of a high fat diet in mothers born of normal birth weight male fetal. Exercise in both mothers born small and of normal birth weight fed a high fat diet male. Mothers on high fat diet and sedentary: reduced the fetal nephron number.
