PHYS30001 Lecture Notes - Lecture 33: Birth Weight, Aorta, Coronary Circulation

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1 Jan 2019
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Low birth weight = reduced response to ach but no difference for nitroglycerin - therefore endothelial function is affected, not vsm. Increased carotid artery stiffness in kids born small. Conclusion: low birth weight is associated with poor endothelium function and increased carotid artery stiffness. Measure of the ability of blood vessels to constrict/ dilate to a particular drug e. g. phenylepherine, acetylcholine, bradykinin. Requires vascular smooth muscle cells (vsmcs) to be active. Dietary restriction in pregnant rats causes hypertension and vascular dysfunction in offspring. Pregnant rats were given a 30% reduction of total diet to investigate the effects on hypertension and blood vessel function. White = control; black = resictriced; left female right male. Conclusion: diet restriction results in increased mean arterial pressure. Males have increased bp earlier, but females catch up. Pregnant rats were given a 30% reduction of total diet to investigate the effects on hypertension and blood vessel (femoral artery) function.

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