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PHYS30005 (33)

Class Notes for PHYS30005 at University of Melbourne

Muscle and Exercise Physiology

PHYS30005 Lecture Notes - Lecture 29: Myosatellite Cell, Myofibril, Conceptual Framework

Lecture 29 Skeletal muscle plasticity 2 Limitations to exercise adaptation Muscle will adapt optimally to exercise that moderately exceeds their capacity Requires a gradual progression in training load in order to maximise...

Physiology
PHYS30005
Charles Sevigny
PHYS30005 Lecture Notes - Lecture 28: Masseter Muscle, Glycolysis, Protein Isoform

Lecture 28 Skeletal muscle plasticity 1 Simplified overview of signalling network controlling skeletal muscle mass with hypertrophy and in muscle atrophy ...

Physiology
PHYS30005
Charles Sevigny
PHYS30005 Lecture Notes - Lecture 30: Methyl Group, Kat5, Cytosine

Lecture 30 Transcriptional regulation Transcriptional regulation of SCs Transcription factors binding to 5 promoter region Pax7, MyoD, MyoG etc. Binding of RNA polymerase (PNA pol II) to the TSS ...

Physiology
PHYS30005
Charles Sevigny
PHYS30005 Lecture 27: Lecture 27 – Muscle regeneration

Lecture 27 Muscle regeneration Sequestial cycle of muscle healing phases after laceration Disruption of muscle tissue homeostasis, caused by injury, generates sequential involvments of various players around 3 main phases ...

Physiology
PHYS30005
Charles Sevigny
PHYS30005 Lecture Notes - Lecture 26: Monocyte, Descending Limb Of Loop Of Henle, Primary And Secondary Brain Injury

Lecture 26 Muscle injury Experimental models of muscle injury Crush muscle in a controlled fashion Ischaemia then reperfusion of muscle Laceration Lengthening contraction Myotoxic injection local anaesthetics and snake ven...

Physiology
PHYS30005
Charles Sevigny
PHYS30005 Lecture Notes - Lecture 24: Tgf Beta 1, Endoderm, Insulin-Like Growth Factor 2

Lecture 24 Myogenesis Myogenesis = the synthesis of new muscle Muscle cells are highly complex full of metabolic and contractile proteins and are huge compared to other cells can be up to 12cm in length! Embryonic or...

Physiology
PHYS30005
Charles Sevigny
PHYS30005 Lecture Notes - Lecture 25: Immunosuppression, Cd133, Cell Therapy

Lecture 25 Myogenesis 2 Post-natal myogenesis Normal post-natal growth (birth adult) is mediated by fibres getting bigger (not myogenesis = hypertrophy) BUT muscles can be damaged myopathies (Dystrophy) ...

Physiology
PHYS30005
Charles Sevigny
PHYS30005 Lecture Notes - Lecture 22: Exon, Reading Frame, Myotonic Dystrophy

Lecture 22 New therapies to improve muscle Gene therapy = delivery of DNA/RNA to correct or compensate What kind of constructs might one deliver? Correction restore expression of a gene that is missing or reduced and/...

Physiology
PHYS30005
Charles Sevigny
PHYS30005 Lecture Notes - Lecture 21: Erythropoietin, Formoterol, Cortisol

Lecture 21 Growth promoting agents and skeletal muscle Therapeutic approaches for muscle wasting disorders 1. Hormonal GH, testosterone, DHEA, SARMs 2. Growth factors IGF-I, IL-15, TGF-beta 3. Other growth...

Physiology
PHYS30005
Charles Sevigny
PHYS30005 Lecture Notes - Lecture 18: Myocyte, Pancreatic Cancer, Chronic Obstructive Pulmonary Disease

Lecture 18 Cancer cachexia Muscle wasting and weakness is caused by a variety of diseases/situations including cancer, COPD, diabetes, denervation, heart failure, disuse atrophy, muscular dystrophies, sarcopenia, chroni...

Physiology
PHYS30005
Charles Sevigny
PHYS30005 Lecture Notes - Lecture 19: Vascular Endothelial Growth Factor, Socs3, Ibuprofen

Lecture 19 The role of inflammation in skeletal muscle maintenance Inflammation is a double-edged sword is a protective immune response but chronic inflammation can cause many problems Cross-talk between damaged fibre...

Physiology
PHYS30005
Charles Sevigny
PHYS30005 Lecture Notes - Lecture 16: Transforming Growth Factor Beta, Proteome, Cachexia

Lecture 16 - Role of E3-ligases inmuscle maintenance & muscle wasting pathways Muscle mass is maintained by incorporation of nuclei and net protein synthesis, very dependent on age of subject Muscle mass is influenced by...

Physiology
PHYS30005
Charles Sevigny
PHYS30005 Lecture Notes - Lecture 9: Lactic Acid, Vasodilation, Angiogenesis

Lecture 9 Cardiorespiratory response to exercise Oxygen uptake during exercise is dependent upon exercise intensity and duration. The oxygen deficit is due to a delay in oxygen delivery and/or mitochondrial respiration...

Physiology
PHYS30005
Charles Sevigny
PHYS30005 Lecture Notes - Lecture 17: Reuptake, Groupon, Cachexia

Lecture 17 Aging and skeletal muscle Changes in life expectancy throughout history a) Changes in environment, nutrition and medical care have extended human life expectancy, especially in the last 200 years (max. lifesp...

Physiology
PHYS30005
Charles Sevigny
PHYS30005 Lecture 20: Lecture 20 – Nutrition to promote muscle metabolism

Lecture 20 Nutritionto promote muscle metabolism Training and sport nutrition To optimise body substrate stores before exercisecompetition To enhance substrate availability during exercise and spare muscle glycogen stores ...

Physiology
PHYS30005
Charles Sevigny

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