PHYS30005 Lecture Notes - Lecture 17: Reuptake, Groupon, Cachexia

• School: University of Melbourne
• Department: Physiology
• Course: PHYS30005
• Professor: Charles Sevigny

Document Summary

Lifespan/health span extension is possible by targeting detrimental effects of ageing, including healthy lifestyle and actionable/drug-treatable molecular targets. B(cid:455) (cid:1006)(cid:1004)(cid:1009)(cid:1004) the (cid:449)o(cid:396)ld"s populatio(cid:374) o(cid:448)e(cid:396) (cid:1010)(cid:1004) (cid:449)ill dou(cid:271)le f(cid:396)o(cid:373) (cid:1005)(cid:1005)% to 22% (2 billion people 60 or older, 400 million 80 or older) Hould(cid:374)"t (cid:271)e a p(cid:396)o(cid:271)le(cid:373) (cid:271)ut agi(cid:374)g is asso(cid:272)iated (cid:449)ith (cid:272)h(cid:396)o(cid:374)i(cid:272) health conditions and increased disability - reduces activity and ability to contribute to society, major burden for health care system. Sarcopenia = age-associated loss of skeletal muscle mass and function. Individuals tend to lose muscle mass at a rate of 1-2% per year after 50. Causes are multifactorial disuse, changing endocrine function, chronic diseases, inflammation, insulin resistance, nutritional deficiencies. Cachexia may be a component of sarcopenia but they are not the same thing. Diagnosis (of sarcopenia) should be considered in all older patients with observed declines in physical function, strength or overall health. Patie(cid:374)ts a(cid:396)e (cid:271)ed(cid:396)idde(cid:374), (cid:272)a(cid:374)"t i(cid:374)depe(cid:374)de(cid:374)tl(cid:455) (cid:396)ise f(cid:396)o(cid:373) a (cid:272)hai(cid:396) o(cid:396) gait speed