PHYS30005 Lecture Notes - Lecture 26: Monocyte, Descending Limb Of Loop Of Henle, Primary And Secondary Brain Injury
25 Jul 2018
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Document Summary
Experimental models of muscle injury: crush muscle in a controlled fashion. Ischaemia then reperfusion of muscle: laceration, lengthening contraction, myotoxic injection local anaesthetics and snake venom (breakdown of muscle fibres) Sequence of muscle injury and repair (always: degeneration, inflammation, regeneration, fibrosis (non-contractile tissue infiltration) Type of injury determines extent of muscle damage, regeneration and fibrosis. Injury only to muscle fibres e. g. myotoxic damage with bupivacaine, snake venom. But is the ecm is compromised e. g. crush, laceration. More severe injury, damage to blood vessels and nerves, less complete regeneration and extensive fibrosis, which severely compromises functional restoration. Loss of muscle function (short term or long term) leads to re-injury, disability, loss of independence, reduced quality of life and (massive) health care costs. Implications for dmd (cid:373)uscles ca(cid:374)(cid:859)t produce force at greater stretch magnitude due to increased susceptibility to contraction-induced injury (compared to normal)
