PHYS30005 Lecture Notes - Lecture 30: Methyl Group, Kat5, Cytosine
25 Jul 2018
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Transcriptional regulation of scs: transcription factors binding to 5(cid:859) promoter region pax7, myod, myog etc, binding of rna polymerase (pna pol ii) to the tss, epigenetic regulation provides additional regulation for gene transcription. Epigenetics = a heritable change in the absence of change in the dna sequence. Almost always involves chromatin = dna + proteins in chromosome: dna methylation, histone modification. The addition of a methyl group (-ch3) to the cytosine base of a cpg dinucleotide. Often occurs at the promoter region of genes (leading to repression) Generally o(cid:272)(cid:272)urs in areas ri(cid:272)h in (cid:858)cg(cid:859) (cid:271)ase pairs (cid:894)cpg islands(cid:895) The methyl group is deposited in the following reaction and sam is derived (predominantly) from the diet (folate) or through the conversion of serine. Note: pregnant woman should have high folate diet to help with all the dna methylation involved in foetal development. How do we turn on/off certain genes? (more specific)
