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Lecture

DEV2011: Lecture 27 summary

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Department
Medicine
Course Code
DEV2011
Professor
Various

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LECTURE 27 Angiogenesis: Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. Angiogenesis is a normal and vital process in growth and development, as well as in wound healing and in the formation of granulation tissue. However, it is also a fundamental step in the transition of tumors from a benign state to a malignant one, leading to the use of angiogenesis inhibitors in the treatment of cancer. Vasculogenesis: Vasculogenesis is the process of blood vessel formation occurring by a de novo production of endothelial cells. Vasculogenesis occurs during embryologic development of the circulatory system. Difference between Angiogenesis and Vasculogenesis: Though similar to angiogenesis, the two are different in one aspect: The term angiogenesis denotes the formation of new blood vessels from pre-existing ones, whereas vasculogenesis is the term used for the formation of new blood vessels when there are no pre-existing ones. For example, if a monolayer of endothelial cells begins sprouting to form capillaries, angiogenesis is occurring. Vasculogenesis, in contrast, is when endothelial precursor cells (angioblasts) migrate and differentiate in response to local cues (such as growt
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