Angiogenesis is the physiological process through which new blood vessels form
from pre-existing vessels. Angiogenesis is a normal and vital process in growth
and development, as well as in wound healing and in the formation of
granulation tissue. However, it is also a fundamental step in the transition of
tumors from a benign state to a malignant one, leading to the use of angiogenesis
inhibitors in the treatment of cancer.
Vasculogenesis is the process of blood vessel formation occurring by a de novo
production of endothelial cells. Vasculogenesis occurs during embryologic
development of the circulatory system.
Difference between Angiogenesis and Vasculogenesis:
Though similar to angiogenesis, the two are different in one aspect: The term
angiogenesis denotes the formation of new blood vessels from pre-existing ones,
whereas vasculogenesis is the term used for the formation of new blood vessels
when there are no pre-existing ones. For example, if a monolayer of endothelial
cells begins sprouting to form capillaries, angiogenesis is occurring.
Vasculogenesis, in contrast, is when endothelial precursor cells (angioblasts)
migrate and differentiate in response to local cues (such as growt