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DEV2011: Lecture 25 summary

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Monash University

LECTURE 25 Haematopoiesis: Haemotopoiesis is the formation of blood cellular components. All cellular blood components are derived from haematopoietic stem cells. In developing embryos, blood formation occurs in aggregates of blood cells in the yolk sac, called blood islands. As development progresses, blood formation occurs in the spleen, liver and lymph nodes. When bone marrow develops, it eventually assumes the task of forming most of the blood cells for the entire organism. However, maturation, activation, and some proliferation of lymphoid cells occurs in secondary lymphoid organs (spleen, thymus, and lymph nodes). In children, haematopoiesis occurs in the marrow of the long bones such as the femur and tibia. In adults, it occurs mainly in the pelvis, cranium, vertebrae, and sternum. Aorta-Gonad-Mesonephros (AGM): The aorta-gonad-mesonephros is a region of embryonic mesoderm that develops during embryonic development from the para-aortic splanchnopleura in chick, mouse and human embryos. It has been suggested that this area, in particular the ventral wall of the dorsal aorta, is one of the primary origins of the definitive haematopoietic stem cell. It contains the dorsal aorta, genital ridges and mesonephros and lies between the notochord and the somatic mesoderm, extending from the umbilicus to the anterior limb bud of the embryo. The AGM region plays an important role in embryonic development, being the first autonomous intra-embryonic site for definitive haematopoiesis.
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