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Class Notes (1,032,694)
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Monash (3,663)
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BCH3042 (23)

Class Notes for BCH3042 at Monash University

Cell signal transduction: Role in cancer and human disease

BCH3042 Lecture Notes - Lecture 22: Phosphatidylinositol (3,4,5)-Trisphosphate, Phosphatidylinositol 4,5-Bisphosphate, Pleckstrin Homology Domain

Lecture 22 PI3K/Akt Signalling And its Role in Cancer PI(3,4,5)P3Recruits PI(3,4,5)P3binding effector proteins to transduce signalling Unstimulated/resting cell (G0 of cell cycle) o Undetectable PI(3,4,5...

Biochemistry
BCH3042
Caroline Speed
BCH3042 Lecture Notes - Lecture 23: Phosphatidylinositol (3,4,5)-Trisphosphate, Tumor Suppressor Gene, Protein Kinase B

Lecture 23 PTEN and Cancer Role PTEN Plays in Regulating PI3K/Akt Signalling PTEN (enzyme): tumour suppressor gene o Dephosphorylate both proteins o Negatively regulates levels of ...

Biochemistry
BCH3042
Caroline Speed
BCH3042 Lecture Notes - Lecture 21: Phosphatidylinositol (3,4,5)-Trisphosphate, Signal Transduction, Inositol

Lecture 21 Phosphoinositides (PIs) 7 of PIs o Act to regulate every aspect of cellular function: movement, death, translation o P13K: Often disregulated in cancers (hyperactivat...

Biochemistry
BCH3042
Caroline Speed
BCH3042 Lecture Notes - Lecture 17: B-Cell Chronic Lymphocytic Leukemia, Navitoclax, Mcl1

Lecture 17 Introduction to Extrinsic Apoptosis Pathway BH3-Only Proteins and Cancer Act as tumour suppressors BAD and BIM trigger cell death Homozygous deletion of BIM is seen in many mantle cell lymph...

Biochemistry
BCH3042
Caroline Speed
BCH3042 Lecture 12: Ras and MAPK Pathway

Lecture 12 Ras and MAPK Pathway Ras Monomeric small GTP binding protein key regulator of cell growth in all eukaryotic cells Relay signals from receptor tyrosine kinases to nucleus to stimulate cell proliferation Biologica...

Biochemistry
BCH3042
Caroline Speed
BCH3042 Lecture Notes - Lecture 15: Lysis, Caspase 3, Western Blot

Lecture 15 Apoptotic Signalling Pathways, Methods and Models I Caspases Help Dictate the Cell Death Pathway Caspases accelerate apoptosis But caspase activity is dispensable for cell death within the intrins...

Biochemistry
BCH3042
Caroline Speed
BCH3042 Lecture Notes - Lecture 14: Caspase, Apoptosis, Cytochrome C

Lecture 14 Cell Death Types of Cell Death Apoptosis: program of cell death (1) o Get nuclear fragmentation Necrosis: accidental cell de...

Biochemistry
BCH3042
Caroline Speed
BCH3042 Lecture Notes - Lecture 19: Complement Membrane Attack Complex, Humanized Antibody, Monoclonal Antibody

Lecture 19 Therapeutic Antibodies Targeting Specific Signalling Molecules (Trastuzumab, Cetuximab, Bevacizumab) Structure and Function of an IgG Antibody Antigen binding occurs via variable (V) domains of an...

Biochemistry
BCH3042
Caroline Speed
BCH3042 Lecture Notes - Lecture 20: Small-Cell Carcinoma, Protein Kinase Inhibitor, Receptor Tyrosine Kinase

Lecture 20 Small Molecule Drugs Targeting Protein Kinases (Erlotinib, Gefitinib, Crizotinib) Active site of protein Kinases is a Major Target for Drug Development ATP-binding pocket lies within a cleft bordered by t...

Biochemistry
BCH3042
Caroline Speed
BCH3042 Lecture 16: Bcl-2 Identification

Lecture 16 Bcl2 Identification Bcl2 Bcl2 (B cell lymphoma2) gene discovered at the t(14;18) chromosome translocation point in 90 of Bcell follicular lymphomas o Translocation of 14 is switched with chromosome 18 o BCells s...

Biochemistry
BCH3042
Caroline Speed
BCH3042 Lecture Notes - Lecture 13: Chronic Myelogenous Leukemia, Receptor Tyrosine Kinase, Chromosomal Translocation

Lecture 13 Chronic Myeloid Leukaemia (CML) and BCR/Abl Single oncogenic mutation causes CML Chromosomal Rearrangement Many affect oncogenes or transcription factors Rearrange the regulatory and coding ...

Biochemistry
BCH3042
Caroline Speed
BCH3042 Lecture 11: Oncogenes

Lecture 12 Oncogenestyrosine Kinase Receptors Protooncogenes and Oncogenes Normal cellular genes that promote cell growth and cell division Important for normal cell survival, growth, development and differentiation Oncoge...

Biochemistry
BCH3042
Caroline Speed
BCH3042 Lecture Notes - Lecture 18: Matrigel, Organoid, Xenotransplantation

Lecture 18 Pre-clinical Validation of Therapeutic Targets Drug Development Path Discovery development pre-clinical studies clinical trials approved therapy o Pr...

Biochemistry
BCH3042
Caroline Speed
BCH3042 Lecture Notes - Lecture 1: Cancer Cell, Growth Factor, Cell Cycle

Lecture 1 The Hallmarks of Cancer Cancer Second only to heart disease as a cause of death Causes much human suffering Cancer results from damage to DNA acquired (exposure to mutagens) or inheri...

Biochemistry
BCH3042
Caroline Speed
BCH3042 Lecture Notes - Lecture 6: Protein Kinase Inhibitor, Histone Deacetylase, Trastuzumab

Lecture 6 Cell Surface Receptors and the Tumour Microenvironment Enzyme-linked Receptors: RTK Family reloaded Single Transmembrane proteins Many are receptors for growth factors Kinase domain on C termi...

Biochemistry
BCH3042
Caroline Speed

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