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Class Notes for BMS3021 at Monash University

Molecular medicine and biotechnology

BMS3021 Lecture Notes - Lecture 10: Skin Grafting, Phagocytosis, Nod Mice

Week 4. MHC and its role in transplantation and autoimmunity, Genetic manipulation of the immune system and transgenics and, Gene targeting in immunology MHC AND ITS ROLE IN TRANSPLANTATION AND AUTOIMMUNITY Transplantation...

Biomedical Sciences
BMS3021
Mike Ryan
BMS3021 Lecture Notes - Lecture 23: Gastric Mucosa, Gastritis, Serology

Week 9. The inflammatory network in cancer and, How do microbes (bugs) cause chronic inflammation and cancer THE INFLAMMATORY NETWORK IN CANCER Inflammation: 4 signs: 1. Pain 2. Redness 3. Heat 4. Swelling caused by change...

Biomedical Sciences
BMS3021
Mike Ryan
BMS3021 Lecture Notes - Lecture 2: Periplasm, Ex Vivo, Non-Homologous End Joining

Week 1. Protein therapy, Antibodies and therapy and, Genetic approaches to disease therapy PROTEIN THERAPY Why make proteins recombinantly? o Cant get it from endogenous sources o For efficient and selective purification o...

Biomedical Sciences
BMS3021
Mike Ryan
BMS3021 Lecture Notes - Lecture 14: Heat Shock Protein, Antibody, Hsp70

Week 6. Polyglutamine proteins and diseases and Alzheimers disease POLYGLUTAMINE PROTEINS AND DISEASES Polyglutamine proteins and disease: o Defined as string of glutamines in a row (more than 7 = Polyglutamine string) o S...

Biomedical Sciences
BMS3021
Mike Ryan
BMS3021 Lecture Notes - Lecture 17: Cell-Mediated Immunity, Clathrin, Egf-Like Domain

Week 7. Atherosclerosis and familial hypercholesterolaemia, Familial haemophagocytic lymphohistiocytosis (FHL), and Cystic fibrosis (CF) ATHEROSCLEROSIS AND FAMILIAL HYPERCHOLESTEROLAEMIA Mutation can be cause disease by m...

Biomedical Sciences
BMS3021
Mike Ryan
BMS3021 Lecture Notes - Lecture 7: Streptokinase, Drug Discovery, Salbutamol

Week 3. Pharmacogenetics, Drug development from laboratory to clinic and Case study Agomelatine PHARMACOGENETICS Pharmacogenetics: is the study of interindividual variation in DNA sequence related to pharmacokinetics or ph...

Biomedical Sciences
BMS3021
Mike Ryan
BMS3021 Lecture Notes - Lecture 5: Psychosis, Penicillin, Pharmacology

Week 2. Key concepts in drug discovery and Pharmacokinectics in drug discovery KEY CONCEPTS IN DRUG DISCOVERY Drug = any chemical substance (other than a nutrient or essential dietary ingredient) that brings about a change...

Biomedical Sciences
BMS3021
Mike Ryan
BMS3021 Lecture Notes - Lecture 20: Pyroptosis, Spasticity, Cytokine Storm

Week 8. Intracellular pathogens (Shigella), Extracellular pathogens (Clostridium) and, Viral pathogens INTRACELLULAR PATHOGENS (SHIGELLA OR BACILLARY DYSENTERY) Bacillary dysentery or Shigellosis Host response gives almost...

Biomedical Sciences
BMS3021
Mike Ryan
BMS3021 Lecture Notes - Lecture 16: Helper Virus, Glycoprotein, Copii

Week 6. Lung and circulatory disease Coagulation and haemophilia COAGULATION AND HAEMOPHILIA Initial injury > break in integral blood vessel > recruit platelets first > surface has assembly of factors that drive formation...

Biomedical Sciences
BMS3021
Mike Ryan
BMS3021 Lecture Notes - Lecture 13: Atomic-Force Microscopy, Surface Tension, Thermodynamics

Week 5. Mechanisms of protein folding and aggregation MECHANISMS OF PROTEIN FOLDING AND AGGREGATION Unfolded proteins are dangerous: hydrophobic groups are exposed which is in danger of interacting with other partial folde...

Biomedical Sciences
BMS3021
Mike Ryan

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