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Class Notes (1,030,088)
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Monash (3,663)
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IMM2011 (16)

Class Notes for IMM2011 at Monash University

Basic immunology: The body's defence system

IMM2011 Lecture Notes - Lecture 18: Microbial Toxin, Somatic Hypermutation, Affinity Maturation
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role of T cells and cytokines in class switching. When b cell that express mhc class 2 interacts with t cell interact and the cd40L ligand on both interacts , this results in synapses formation and leading to signaling i...

Science - Immunology
IMM2011
A/P Frank Alderuccio
IMM2011 Lecture Notes - Lecture 17: Mhc Class Ii, Antigen-Presenting Cell, Innate Immune System
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Delineate the mechanism of antigen recognition and B cell activation. - - On the surface of b cell there are multiple BCR expressed, these can be either igM or igD antibodies. However these only bind to ext...

Science - Immunology
IMM2011
A/P Frank Alderuccio
IMM2011 Lecture Notes - Lecture 16: Immunoglobulin Class Switching, Germinal Center, Affinity Maturation
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Features of B cell: What are the key features associated with the germinal center reaction 1) Germinal centre reaction: Where fully developed antibody response occurs in this germinal centre which are formed in lymphoid f...

Science - Immunology
IMM2011
A/P Frank Alderuccio
IMM2011 Lecture Notes - Lecture 15: Cell-Mediated Immunity, Mycobacterium Tuberculosis, Intracellular Parasite
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Th17: also fight extracellular pathogens: Secrete IL17 and Il22 Fight viral infection Cell mediated immunity plays a role in fighting intracellular pathogens such as mycobacterium tuberculosis which lives and multiples ...

Science - Immunology
IMM2011
A/P Frank Alderuccio
IMM2011 Lecture Notes - Lecture 14: Interferon Gamma, Wound Healing, Mast Cell
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Lecture 3 differences between Th1 and Th2 cells While Th1 cells tend to generate responses against intracellular parasites such as bacteria and viruses, Th2 cells produce immune responses against helminths and other extr...

Science - Immunology
IMM2011
A/P Frank Alderuccio
IMM2011 Lecture Notes - Lecture 13: Signal Transduction, Cell Adhesion, Cell Adhesion Molecule
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when T cell meets at DC This figure shows Receptors and ligand needed for T cell activation. The first step in t cell activation involves TCR binding to MHC peptide complex and TCR co receptors (CD4) shown in the diagram...

Science - Immunology
IMM2011
A/P Frank Alderuccio
IMM2011 Lecture Notes - Lecture 12: Mycobacterium Tuberculosis, Antibody, Cell-Mediated Immunity
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T CELL . Recap: What is MHC: Major histocompatibility complex Dendritic cell: only professional APC that can activate naive T cell. three types of antigen presenting cell :macrophages b cell and dendritic cell. only dendri...

Science - Immunology
IMM2011
A/P Frank Alderuccio
IMM2011 Lecture Notes - Lecture 5: Opsonin, Interleukin-1 Family, Blood Vessel
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LECTURE 5:IMMUNE CELL MIGRATION AND COMMUNICATION (CYTOKINES) Learning objecitve 1: Define cytokines and chemokines in the context of immunity - Cytokines are small soluble protein involved in activating immune ...

Science - Immunology
IMM2011
A/P Frank Alderuccio
IMM2011 Lecture Notes - Lecture 10: Transplant Rejection, T Cell, Antigen Processing
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LECTURE : 10 and 11: MHC MOLECULE Major histocompatibility complex: Membrane bound protein that function to show activate t cell by displaying antigen to it. Describe the structure of MHC class I and MHC CLASS II: MHC clas...

Science - Immunology
IMM2011
A/P Frank Alderuccio
IMM2011 Lecture 7: Lesson #3- t and b cell development
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LESSON 3:T development and central tolerance: T and B cells develop in different locations T cells originate from the bone marrow as precursor cells BUT they develop in the THYMUS Before entering the thymus they are not ye...

Science - Immunology
IMM2011
A/P Frank Alderuccio
IMM2011 Lecture Notes - Lecture 7: Rna, Terminal Deoxynucleotidyl Transferase, Main Sequence
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Lesson 2 t and b cell development T cell: Originated from the bone marrow as a precursor cell but they complete their development in the thymus. B CELL: Develop in the bone marrow Primary lymphoid organs:sites of lymphoc...

Science - Immunology
IMM2011
A/P Frank Alderuccio
IMM2011 Lecture Notes - Lecture 6: B-Cell Receptor, Complementarity-Determining Region, Pattern Recognition Receptor

Online lesson 1: T and b cell development: An antigen : molecule that will bind to an antigen receptor; these are the T cell antigen receptor (TCR) and the B cell antigen receptor (BCR ) Types of antigens that bind to B ce...

Science - Immunology
IMM2011
A/P Frank Alderuccio
IMM2011 Lecture Notes - Lecture 4: Adaptive Immune System, Innate Immune System, Neutropenia

Linking innate and adaptive immunity: Week 2 L3: Function of immune system: 1) Defence: against infectious agents Bacteria , fungi , viruses, helminths Long term memory 2) homeostasis Recognises self, what compromises o...

Science - Immunology
IMM2011
A/P Frank Alderuccio
IMM2011 Lecture Notes - Lecture 3: Tlr3, Innate Immune System, Lipopolysaccharide

WEEK 2 :L1 Innate Immunity what is meant by the term innate immunity: Innate immunity is defence that is always present in a normal host cell, it consist of numerous physical , cellular and soluble features that are read...

Science - Immunology
IMM2011
A/P Frank Alderuccio
IMM2011 Lecture Notes - Lecture 2: Lymph Node, Thymus, Mast Cell

Lecture 3 : WEEK 1: Name the primary lymphoid organs and their main Purpose Primary lymphoid organ: where the immune cells are made and mature 1) Bone marow HSC found here: Generation of B cell , and granulocytes( neutrop...

Science - Immunology
IMM2011
A/P Frank Alderuccio
Laboratory Basics - Reference Guides

Lab safety is the cornerstone principle in this compelling Guide. All international safety symbols are clearly defined, with all basic lab glassware and equipment depicted by text description and diagrams. The Guide also p...

ANAT - Anatomy
ANAT 14
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