IMM2011 Lecture Notes - Lecture 7: Rna, Terminal Deoxynucleotidyl Transferase, Main Sequence
23 Jun 2018
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Lesson #2- t and b cell development
T cell:
- Originated from the bone marrow as a precursor cell but they
complete their development in the thymus.
B CELL:
- Develop in the bone marrow
Primary lymphoid organs:sites of lymphocytes development.
- Thymus and bone marrow
Secondary lymphoid organs
- spleen and lymph nodes through the body.
- Where the immune response is generated
CDR: Complementarity determining region
- Where the biggest variability in the amino acid sequence lies in.
BCR/ antibody:
- Each heavy and light chain has 3 CDR region ( CDR1, CDR2,
CDR3)
TCR:
- Each of the alpha chain and beta chain of the TCR molecule has 3
CDR.
For both the binding site specifc shape to which the antigen binds is
determined by a combination of 6 DRS.
- Location where the variability in receptor is found.
Generating antigen receptor:
B cell receptor:
1) heavy chain:
Constant part conains three gene segments:
CH1, CH2 , CH3
Variable region: contains three gene segments:
V- variable
D- diversity
J- joining
2) Light chain
Constant region: one gene segment (CL)
Document Summary
Originated from the bone marrow as a precursor cell but they complete their development in the thymus. Spleen and lymph nodes through the body. Where the biggest variability in the amino acid sequence lies in. Each heavy and light chain has 3 cdr region ( cdr1, cdr2, Each of the alpha chain and beta chain of the tcr molecule has 3. For both the binding site specifc shape to which the antigen binds is determined by a combination of 6 drs. Location where the variability in receptor is found. Variable: alpha contains two gene segment v and j segment. Receptor is produced when gene segments are joined, this involves the. Dna splicing and rna being produced into a protein. There are multiple variable gene segment, multiple diversity gene segment and multiple. These can be randomly joined producing different vdj segment : different receptors can be produced.
