IMM2011 Lecture Notes - Lecture 16: Immunoglobulin Class Switching, Germinal Center, Affinity Maturation
14 Jul 2018
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Document Summary
What are the key features associated with the germinal center reaction: germinal centre reaction: Where fully developed antibody response occurs in this germinal centre which are formed in lymphoid follicles and these also require the help of follicular helper t cell . Here through fht cell b cell undergo isotype switching and somatic mutation of ig genes and results in high affinity b cell being selected to different into long lived memory cells. Antibodies recognise antigens proteins, polysaccharides, nucleic acids, lipids, and small chemical. Antibodies can target extracellular pathogens,unicellular or multicellular, for destruction. Phases of humoral immune response: in which naive b cell recognise antigen and under the influence of helper t cell and other stimuli. The b cell then proliferates amd expand by clonal expansion it then undergoes differentiation to either undergo antibody secretion (same as what captured the pathogen)
