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Semester
Class Notes (1,044,161)
AUS (35,213)
Monash (3,700)
PHA (25)
PHA3801 (21)

Class Notes for PHA3801 at Monash University

Principles of pharmacology

PHA3801 Lecture Notes - Lecture 21: Timolol, Glucocorticoid, Esmolol

Sympathetic (Adrenergic) Drugs Adrenoceptor agonists: Directly-, indirectly- and mixed-acting sympathomimetics. Adrenoceptor antagonists: Alpha- and beta-adrenoceptor antagontists prevents action of NA/A Adrenergic neuron...

Science - Pharmacology
PHA3801
All Professors
PHA3801 Lecture Notes - Lecture 20: Carbamate, Carbachol, Edrophonium

Parasympathetic (cholinergic) Drugs Parasympathetic agent Effect Agonist Stimulates the receptor, mimics ACh Antagonist ...

Science - Pharmacology
PHA3801
All Professors
PHA3801 Lecture Notes - Lecture 22: Distal Convoluted Tubule, Cytosol, Alkylation

Pharmacokinetics metabolism and excretion Drugs are foreign compounds (xenobiotics). Metabolism changes drug properties: more ionized, more water soluble, less pharmalogically active. Phase 1: (derivative). Oxidation, re...

Science - Pharmacology
PHA3801
All Professors
PHA3801 Lecture Notes - Lecture 19: Broadspectrum, Rifampicin, Ciprofloxacin

Principles of antibacterial therapy - Inc life span since introduction of antimicrobial therapy. Criteria of indication: restrict use of ABs to unavoidable situations. Risk of resistance, unwanted side effects (allergies, ...

Science - Pharmacology
PHA3801
All Professors
PHA3801 Lecture Notes - Lecture 16: Heparin, Microcephaly, Salbutamol

Elderly, children, pregnancy and lactation Variability: If not taken into account lack of efficacy or unexpected side-effects age, genetic factors, immunological factors, pathological states (kidney/liver), drug interacti...

Science - Pharmacology
PHA3801
All Professors
PHA3801 Lecture Notes - Lecture 12: Adme, Quinolone, Maltose

Drug interactions Polypharmacy: concurrent use of multiple medications, inc w age of pt. Also common in pts w long- term chronic illnesses (e.g. AIDS). Drug-drug interaction (DDI): Modification of drug disposition and/or e...

Science - Pharmacology
PHA3801
All Professors
PHA3801 Lecture Notes - Lecture 11: Skeletal Muscle, Cerebral Circulation, Spasm

1 General Anaesthesia Mandrakes (sleep), Opiates (pain), Curare (muscle relax), cocaine (LA). Anaesthesia: Admin of (combinations) of drug(s) to achieve 5 conditions for loss of pain sensation hypnotic, analgesic, musc...

Science - Pharmacology
PHA3801
All Professors
PHA3801 Lecture Notes - Lecture 13: Tinea Nigra, Thymol, Astringent

Disinfection/Antiseptics: Sterilisation: Aim to destroy ALL living microorganisms Antiseptics: used on ext body surfaces Disinfection: Aims to remove/destroy pathogenic microorganisms (no longer able to pass on an infecti...

Science - Pharmacology
PHA3801
All Professors
PHA3801 Lecture Notes - Lecture 15: Imipramine, Depolarization, Central Nervous System Depression

Local anesthetics Lipophillic (aromatic portion) Hydrocarbon chain (ester or amide), hydrophilic (amine portion). - Nerve cell needs to be stimulated above threshold by influx of Na+ causing more Na channels to open in...

Science - Pharmacology
PHA3801
All Professors
PHA3801 Lecture Notes - Lecture 17: Tight Junction, Cirrhosis, Degranulation

Mechanism of drug action Pharmacodynamics: Mechanism of drug action, describes what the drug does to the body. Understand how drugs exert their effects at the cellular and/or molecular level. Interaction w receptors: Asth...

Science - Pharmacology
PHA3801
All Professors
PHA3801 Lecture Notes - Lecture 14: Substance P, Tramadol, Allodynia

Opioids Opium: latex of unripe poppy pod containing morphine, codeine, thebaine, papaverine etc. Endorphins: Released from pituitary gland and hypothalamus into CNS, SC and bloodstream (triggered by prolonged exercise, pa...

Science - Pharmacology
PHA3801
All Professors
PHA3801 Lecture Notes - Lecture 5: Gingivitis, Cyp3A4, Inflammatory Bowel Disease

Antibacterial Drugs 2: Bacteriostatic Inhibitors of protein synthesis Tetracycline: Mechanism: Binds to 30S ribosomes, prevents attachment of aminoacyl tRNA to mRNA ribosomal complex. Stops synthesis of peptide chain no p...

Science - Pharmacology
PHA3801
All Professors
PHA3801 Lecture Notes - Lecture 1: Glycosaminoglycan, Halothane, Hyperthyroidism

Anticoagulant & Antiplatelet agents Clot formation: Damage endothelium reveals underlying collagen + other proteins platelets aggregate and adhere to surface to form temporary plug blood clotting factors form strong, dur...

Science - Pharmacology
PHA3801
All Professors
PHA3801 Lecture Notes - Lecture 9: Area Postrema, Maleic Acid, Ionic Bonding

CNS transmitters and receptors Synaptic transmission: Communication bw 2 nerve cells. AP in nerve terminal opens Ca channels Ca entry causes vesicle fusion w membrane and transmitter release (into synaptic cleft) Recept...

Science - Pharmacology
PHA3801
All Professors
PHA3801 Lecture Notes - Lecture 10: Exponential Decay, Intravenous Therapy, Sodium Thiopental

Applied Pharmacokinetics Applied pharmacokinetics: mathematical modeling to characterize the concentration of the drug in the blood vs time after dose. - Absorption, distribution, elimination Optimise treatment according ...

Science - Pharmacology
PHA3801
All Professors
Laboratory Basics - Reference Guides

Lab safety is the cornerstone principle in this compelling Guide. All international safety symbols are clearly defined, with all basic lab glassware and equipment depicted by text description and diagrams. The Guide also p...

ANAT - Anatomy
ANAT 14
All Professors

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