PHY3171 Lecture Notes - Lecture 12: Angiotensin-Converting Enzyme, Angiotensin-Converting Enzyme 2, Angiotensin
10 Feb 2019
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Increases bad" lipid profile (estrogen has opposite effect) Enhances recruitment of inflammatory cells, production of cytokines. Pressure natriuresis: shifts to higher levels greater pressure to excrete a level of salt. In kidneys and large vessels is a constrictor: testosterone increases renin and ace activity pressor arm. The pressor arm of the renin-angiotensin system (ras) leads to increase in blood pressure. Renin is an enzyme which is secreted by the juxtaglomerular cells in the kidney. Angiotensin i is then converted to angiotensin ii by angiotensin converting enzyme (ace). Angiotensin ii now acts on at1r receptors to cause sodium retention, vasoconstriction and. It begins with angiotensinogen which is split to form angiotensin i, through the action of renin. vascular growth (thickening of vessel walls), which all enable blood pressure to increase. The depressor arm leads to decreased blood pressure. Through the conversion of ang i and ang ii to ang (1-9) and ang (1-7), respectively, by ace2.
