MFAC1521 Lecture Notes - Lecture 29: False Positive Rate, Odds Ratio, Statistical Hypothesis Testing
29 Jun 2018
School
Department
Course
Professor
Newborn Screening: Clinical and population aspects, delivery and
organization
By Veronica Wiley
Learning outcomes:
• Overview of newborn dried blood spot screening in Australia
• Understanding of assessing disorders/tests
Screening tests
• Not intended to be diagnostic
• Sorts out apparently well persons who might not have the disease from those who might have the
disease
• Persons with a positive or suspicious finding must be referred for diagnostic testing
• Criteria for screening tests (Wilson and Jungner, 1968)
o Targets an important health problem (significant mortality and morbidity)
o Presence of facilities for diagnosis and treatment
o Test acceptable to the population
o Natural history of disease understood (if left untreated)
o Recognizable latent or early symptomatic stage (means that screening can find out first
before all the clinical signs and symptoms appear)
o Costs economically balanced
Document Summary
Newborn screening: clinical and population aspects, delivery and organization. Learning outcomes: overview of newborn dried blood spot screening in australia, understanding of assessing disorders/tests. Screening tests: not intended to be diagnostic. Sorts out apparently well persons who might not have the disease from those who might have the disease. 1996 was the year of tandem mass spectrometry, which could test for a large number of disorders from the same sample at the same time. Timely intervention in these disorders significantly reduces morbidity, mortality and associated disabilities. ": https://www. hgsa. org. au, recommended provided that, there is a benefit for the baby from early diagnosis, benefit is reasonably balanced against financial and other costs: Publicly funded within the public health sector: cost of each screening test for ~50 different disorders:
