BIOL2202 Lecture Notes - Lecture 1: Allosteric Regulation, Gtpase, Protein Folding

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7 Dec 2018
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Transcriptional and translational complexes are examples of cellular machines. Dalton standard unit used to measure mass at a molecular or atomic scale. Svedberg rate/velocity of sedimentation on a centrifuge. Facilitates complexity and diversity in function and regulation. Covalent modifications that changes protein structure with varied consequences: changes activity, target for degradation, changed cellular location, changed structural organisation. The ca2+/cam switch: opens up the catalytic site on kinase to allow phosphorylation. Change in protein structure/function due to non-covalent binding by a ligand. The gtpase switch: ligand binding changes protein structure to increase enzymatic activity, switch out gdp for gtp, gtpase activating protein increase gtpase activity to turn the system off, often used in signal transduction. Kinesin a microtubule motor require for cellular transport. Atp binding and hydrolysis cy the motor domains drives the walking motion". Ubiquitin chains recognised by 19s regulatory subunit. 19s-binding directs target protein in the core for proteolysis.

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