BIOL2202 Lecture Notes - Lecture 34: Mutagen, Apoptosis, Carcinogen

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blueclam798

20 Dec 2018

School

Department

Biology

Course

BIOL2202

Professor

James Fraser

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Document Summary

Induction of angiogenesis: angiogenesis is the growth of new blood vessel, blood vessels that grow into the tumour can allow tumour to grow. Immortalisation: blockage of the pathways leading to cell death which can allow cancerous cells to survive. Usually cancer results from a mutation in two major types of genes controlling cell proliferation: In sporadic cases, individuals require two mutations (one in each allele) to be affected. In familial cases, individuals only require one additional mutation to be affected. Germline mutations always need somatic mutations for cancer to happen: cancer can be achieved with less somatic mutations if the germ lines cells are mutated. Spectral karyotype analysis: each chromosome is painted in a different colour, used to identify regions in the genome that originated from the same chromosome, this process can indicate translocation (when one chromosome is made of two different colours)

Related Questions

Question 10

A microscope image of a cell in interphase is treated with dyes to stain the nucleic acids (DNA and RNA). This image probably displays ______.

		visible nucleoli
		separate visible chromosomes
		visible spindle fibers

1 points

Question 11

To observe plant cells undergoing mitosis, the best plant tissue to isolate would be ______.

		a section of the root tip
		a section of the mature fruit
		a section of the main stem

1 points

Question 12

Owen observes a slide containing whitefish blastula sections. He finds a cell with visible spindle lines extending from two points on opposite sides of the cell and chromosomes as small black Xs halfway between the two poles. What stage of the cell cycle is Owen observing?

		anaphase
		metaphase
		prometaphase

1 points

Question 13

What structural feature can you use to distinguish between DNA-stained onion cells in anaphase and telophase?

		Sister chromatids separate as anaphase ends and telophase begins.
		The vesicles forming a cell plate appear around the onset of telophase.
		The chromosomes are clustered at visible spindle poles during anaphase.

1 points

Question 14

A carcinogen is any substance or environmental condition that ______.

		increases the frequency of mutation
		causes direct damage to DNA
		inhibits mitosis in cancer cells

1 points

Question 15

Angelina observes a slide containing whitefish blastula sections. She finds a cell with visible spindle lines extending from two points on opposite sides of the cell and chromosomes as small black Xs halfway between the two poles. What intracellular structure forms each of the two points on opposite sides of this cell?

		a metaphase plate
		a cell plate
		a pair of centrioles

1 points

Question 16

Which of the following best describes the relationship between interphase and the cell cycle?

		Interphase is a gap between rounds of cell division.
		Interphase comprises a large majority of the cell cycle in almost all cells.
		Interphase comprises a large majority of the cell cycle in slowly and non-dividing cells.

Question 17

Radiation therapy and chemotherapy are cancer treatments that primarily attack cancer cells through ______.

		activating apoptosis in any rapidly dividing cells to kill off tumor cells
		destroying the blood vessels in cancerous tumors to block the flow of nutrients
		damaging DNA to the extent that cells die if they cannot repair the damage

yellowcat500

13. The arms of a human and the wing of a bat are _________________ structures, composed of the same bones that have been modified for different functions.

analogous

vestigial

c.	homologous

d.	convergent

14. Xeroderma pigmentosum is an autosomal recessive genetic disorder. People who are homozygous for the disease-causing allele have skin that is damaged by exposure to ultraviolet radiation; this can lead to skin cancer at an early age. The mutation that causes this disorder is in a gene that functions:

a.	to repair DNA by excising (removing) nucleotides damaged by UV light.

b.	in lysosomes, to break down lipids that otherwise accumulate in the nervous system.

c.	to produce the UV blocking pigment melanin in the skin cells

d.	in red blood cells to carry oxygen to the skin.

15. The Amish are a religious sect descended from a small group of colonists who came to the United States over 200 years ago. Their religious beliefs have kept them isolated from society. The Amish have a much higher than average incidence of both polydactyly (extra fingers and toes) and dwarfism in their communities. This is most likely explained by:

a.	inheritance of acquired characters.

b.	the founder effect.

c.	disruptive selection.

d.	natural selection.

16. In the structure of DNA that Watson and Crick proposed, the sides of the "ladder" of the DNA molecule are always the same distance apart, making the molecule a constant width. This occurs because when the bases hydrogen bond to form the rungs of the "ladder", a:

a.	purine always pairs with a pyrimidine.

b.	purine always pairs with a purine.

c.	pyrimidine always pairs with a pyrmidine.

d.	The structure of the double helix is not determined by how the bases pair.

17. The RNA transcript of DNA that travels to the cytoplasm, carrying the instructions to make a protein, is called:

rRNA.

tRNA.

mRNA.

d.	RNA polymerase.

18. When DNA is replicated, the error rate is approximately one error for every 10,000 nucleotides copied. However, that error rate is reduced to only 1 error for every 1 billion nucleotides. The DNA sequence is "corrected" by:

a.	repeating S phase to see if the error rate is lower the second time around.

b.	enzymes that proofread the DNA and repair errors.

c.	messenger RNA during the process of transcription.

d.	Any errors made during DNA replication cannot be corrected. If errors are detected after S phase, the cell is destroyed.

19. Mendel's principle of segregation says that:

a.	when gametes are formed, each gamete receives only one allele for a particular gene.

b.	some genes are dominant to others.

c.	a testcross must be used to determine the genotype of an organism with a dominant phenotype.

d.	all of the above

20. Tay-Sachs disease is lethal before reproductive age, but the allele persists in Louisiana French Canadians because:

a.	it is a dominant allele.

b.	new mutations causing this disease are common in that population.

c.	it is not expressed in the phenotype of heterozygous individuals.

d.	the disease is contagious and can be transmitted by nonheritable means.

21. Physical features that are similar in organisms which are not closely related to each other are most likely a result of ____________. A good example of this is the similarities seen between some marsupial and placental mammals.

a.	natural selection.

b.	adaptation to similar environments

c.	convergent evolution

d.	All of the above phrases can be used to correctly fill this blank.

22. In humans, which of the following sex chromosome compliments could be found in males?

23. The proteins that are associated with eukaryotic chromosomes:

a.	help to package the DNA within the nucleus.

b.	are involved in gene expression, through binding with the DNA.

c.	may be replicating or transcribing the DNA.

d.	All of these are true of proteins that are associated with eukaryotic chromosomes.

24. A sequence of DNA nucleotides that contains the information to produce a single protein is a(n):

codon.

gene.

c.	polypeptide.

d.	anticodon.

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BIOL2202 Lecture Notes - Lecture 34: Mutagen, Apoptosis, Carcinogen

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