DENT3060 Lecture Notes - Lecture 24: Pyroptosis, Necroptosis, Ripk1
Document Summary
Cell death essential for multicellular organisms (embryogenesis, reproduction, immune regulation: necrosis: cell death caused by injury/infection, sends alarm signals to body. Inflammation central to host resistance to infection & normal processes (cell death, regeneration) Cell death/replacement normal but controlled; if not, release of cellular contents into local env (cid:396)elease (cid:858)da(cid:374)ge(cid:396)(cid:859) sig(cid:374)als & onset of inflammatory responses. Natural (anti-inflammatory: apoptosis, autophagy: cell degrades own components by enclosing them in vesicle, which subsequently fuses with lysosome, tightly regulated & plays normal part in cell growth, development & homeostasis. Pyroptotic: early loss of plasma membrane integrity + shedding of membrane vesicles. Both: demonstrate nuclear condensation & internucleosomal dna fragmentation. Pyrotoptic: >volume of cytoplasmic compartment; apoptosis:
