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Class Notes for PHRM3011 at University of Queensland

Quality Use of Medicines B1

PHRM3011 Lecture Notes - Lecture 18: Nephritis, Question Time, Digoxin
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Anaemia is associated with mortality in dialysis pts if iron deficient ferritin 100500 if low start ion sup if iron replete start Acute Kidney Disease Causes obstruction o bladder neck obstruction most common o ureteri...

Pharmacy
PHRM3011
Peter Moyle
PHRM3011 Lecture Notes - Lecture 17: Fenofibrate, Calcitriol, Colchicine
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cervical cancer PK monitoring TDM performed for cyclosprorines, tacrolimus, sirolimus and everolimus want a measure of overall drugexposure TDM (therapeutic drug monitoring) maintaining levels within a predefined range...

Pharmacy
PHRM3011
Peter Moyle
PHRM3011 Lecture Notes - Lecture 17: Phosphate Binder, Digoxin, Pulmonary Edema
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Antiproliferatives azathioprine, mycophenolate long term therapy Inhibit DNA synthesis preventing activated Tcells from proliferating large PK variability between pts so need close TDM (therapeutic drug monitoring) AE...

Pharmacy
PHRM3011
Peter Moyle
PHRM3011 Lecture Notes - Lecture 14: Hypochromic Anemia, Titration, Nuclear Material
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ACEIs Delay progression of disease Initial dose avoid first dose hypotension Increase dose at least every 2 weeks get to max dose tolerated by pt SEs couch, hyperkalaemia, hypotension, headache, dizziness, nausea, renal im...

Pharmacy
PHRM3011
Peter Moyle
PHRM3011 Lecture Notes - Lecture 15: Platelet, Polyacrylonitrile, Jejunum
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Haemoglobin 4 protein molecules (2a2 and 2b2) haem iron (O2 binds to) o mostly recycled o only requires 1 mg daily to replace loss o diet = 1020mg daily Microcytic Anaemia Iron deficiency anaemia (hypochromic microcytic...

Pharmacy
PHRM3011
Peter Moyle
PHRM3011 Lecture Notes - Lecture 11: Hyperlipidemia, Lipoprotein, Naproxen
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Prevention Drugs Aspirin lifelong all pts. with STEMI and NSTEMI 75mg, 100mg, 150mg daily increased bleeding and same efficacy with 300mg due to COX2 inhibition Dual Antiplatelet Therapy all pts. with STEMI and NSTEMI...

Pharmacy
PHRM3011
Peter Moyle
PHRM3011 Lecture Notes - Lecture 12: Chest Pain, Hypercholesterolemia, Felodipine
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o stop if CK > 10X normal 50 of max dose = >80 LDL lowering Some evidence of high dose benefit in coronary heart disease DIs simva and atorva metabolised via CYP3A4 fluva metabolised by CYP2C9 major, CYP3A4minor prava a...

Pharmacy
PHRM3011
Peter Moyle
PHRM3011 Lecture Notes - Lecture 16: Fibrin, Ureter, Calcineurin
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Complications hypertension hypotension infection nauseavomiting hyperlipidaemiaTGs disequilibrium cramps itching headache Advantages high solute clearance close pt monitoring technique generally not anissue ea...

Pharmacy
PHRM3011
Peter Moyle
PHRM3011 Lecture Notes - Lecture 13: Hepatotoxicity, Cyp2D6, Orthopnea
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Managing Stable Angina Beta Blockers first line decrease pulse, decrease BP, decrease contractility = decreased myocardial O2 demand do not stop abruptly (withdraw over 2 weeks) SEs fatigue, nightmares, bradycardia, hy...

Pharmacy
PHRM3011
Peter Moyle
PHRM3011 Lecture Notes - Lecture 11: Cardiac Output, Angina Pectoris, Skeletal Muscle
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At ED pt. will get ECG, blood tests and morphine for pain 33

Pharmacy
PHRM3011
Peter Moyle
PHRM3011 Lecture Notes - Lecture 8: Hyperlipidemia, Amlodipine, Oxprenolol
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grade 3 hypertension isolated systolic hypertension high absolute risk indigenous BP Measurement mercury sphygmomanometer (best using hand pump or stethoscope) or instrument errors with machines white cost syndrome ...

Pharmacy
PHRM3011
Peter Moyle
PHRM3011 Lecture Notes - Lecture 2: Cyp2B6, Suicidal Ideation, Bupropion
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Calculating Nicotine Dependence High Dependence 30 per day Within 5 minutes of waking 2030 per day Moderate Within half an hour ofwaking 1020 cigarettes per day Lowmoderate no craving with half an hourof waking 110 cigaret...

Pharmacy
PHRM3011
Peter Moyle
PHRM3011 Lecture Notes - Lecture 10: Fibrin, Nonsteroidal Anti-Inflammatory Drug, Prothrombin Time
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Options for VTE Prophylaxis Drug Dose SEs Renal impairment Duration Drug Interactions Heparin SC 5000units 2 Thrombocytopenia* No dose reduction (UFH) 3td Enoxaparin SC 40mg d in high creatinine clearance 710days (LMWH) ri...

Pharmacy
PHRM3011
Peter Moyle
PHRM3011 Lecture Notes - Lecture 4: Sympathomimetic Drug, Psyllium, Pulmonary Hypertension
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Very low energy diets (VLED) o <800 kcalday or <3350KJday o replace all meals with a specific meal replacement formula during the intensive early phrase o high proteinlow carb diets induce fat burning and milkketosis o ge...

Pharmacy
PHRM3011
Peter Moyle
PHRM3011 Lecture Notes - Lecture 6: Diltiazem, Electrophysiology, Disopyramide
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CVDs Drug Treatments Disease Drugs Used Hypertension ACE or ARB or calcium channel blocker (first line) Thiazide (diuretic) then beta blocker Or combination of above Stoke Thrombolytic + antiplatelets + ACEI + statin H...

Pharmacy
PHRM3011
Peter Moyle

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