PHRM3011 Lecture Notes - Lecture 15: Platelet, Polyacrylonitrile, Jejunum
Document Summary
Haem iron (o2 binds to: mostly recycled, only requires 1 mg daily to replace loss, diet = 10-20mg daily. Iron deficiency anaemia (hypochromic microcytic anaemia) causes: chronic blood loss, childhood, pregnancy, lactation, menses, vegetarian or vegan diet. Values tx o treat underlying cause iron supplement (100mg elemental iron per day) ferrous sulphate 200mg (67mg fe++) for 4-6 months (ferro grad has. 100mg fe++: best absorbed on empty stomach. Parenteral iron: dose = bodyweight x (target actual) x 0. 24 + iron depot. Monitoring: hb, serum fe, transferrin, transferrin saturation, ferritin, reticulocytes, expect an increase of hb (2g/l every 3 weeks) Subdivision megaloblastic anaemia: liver disease, hypothyroidism, copd, chronic alcoholism, accelerated. Causes erythropoiesis: poison (alcohol, congenital defects antivirals, chemotherapy, colchicine, congenital defects. B12 o essential co-factor in dna synthesis and cellular metabolism: absorbed in ilium, pernicious anaemia. Tx o replacement of b12 deficiency: 3-10mg im over the course of 2-4 wks, 1 mg alternate days for two weeks or deficiency (pernicious anaemia)