PHRM4011 Lecture Notes - Lecture 5: Bisphosphonate, Edema, Adrenal Insufficiency
Document Summary
Ceasing statins: benefits: secondary benefits for cvd, harm: se myalgia, rhabdomyolysis, fatigue, reduce dose or cease if px has limited life expectancy/low cvd risk stop immediately. Ceasing benzos: benefits: modest sleep benefit, harm: se (confusion, falls, daytime sleepiness), dependence, reduce dose or cease reduce by 20%/6 weeks. Creatinine protein intake creatinine turnover 90-95% renally filted (retained), 5-10% secreted by distal tubule. Conditions/meds affect it: nsaid constricts afferent arteriole pressure drops acute kidney injury, arb/acei dilate efferent arteriole no pressure acute kidney injury, dehydration. Egfr don"t need weight easier, crcl needs weight more accurate. 98% k in cell do not use haemolysed test. Meds: nsaid hypernatraemia, hyperkalaemia, potassium-sparing diuretics hyponatraemia, hyperkalaemia, digoxin shifts potassium out (more gradient/severe if hypokalaemia) hyperkalaemia. Insulin hypokalaemia: acei/arb hyponatraemia, hyperkalaemia, corticosteroids hyponakalaemia, diuretics (loop/thiazide) hyponatraemia, hypokalaemia, salbutamol nebules hypokalaemia, ssri hyponatraemia, hypokalaemia, cancer hyponatraemia, hypercalcaemia, mg deficiency hypokaelaemia.
