PUBH2007 Lecture Notes - Lecture 5: Statistical Parameter, Null Hypothesis, Blood Pressure

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PUBH2007 LECTURE FIVE
Revision of Normal probabilities and sampling distributions
‘eferece or oral rage for idividual easureets
Definition of statistical inference
Reasoning of statistical estimation
Calculation of a confidence interval
Interpretation of a confidence level
How confidence intervals behave
Writing hand: lurking variable therefore eliminated all left handed participants
Greater spread among men (as per SD)
Distributions for grip strength:
Women:
68% between 25.1 and 34.9 kg
(mean ± 1 std dev = 30.012 ± 4.864)
95% between 20.3 and 39.7 kg
99.7% between 15.4 and 44.6 kg
Men
68% between 40.7 and 54.0 kg
95% between 34.0 and 60.7 kg
99.7% between 27.4 and 67.4 kg
Reference or 'normal' range: values corresponding to 95% limits are sometimes called the reference
range.
E.g. Right grip strength females: 95% between 20.3 and 39.7 kg
Chance of a female in this age group having right grip strength outside this range (i.e., <20.3 or > 39.7)
is less than 5% or probability (P)< 0.05, (or P<0.025 for each tail separately).
Where an individual is expected to sit, used in diagnostics.
Doesn't necessarily mean that those with a grip strength outside normal range are unwell.
Note: 1, 2 and 3 standard deviations are approximations.
Exact values can be obtained from tables, calculators or using statistical software.
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R COMMANDER: MEAN 0, SD 1 and values 0.025 and 0.975 for 95%
If probability = 0.95, exact values are mean +/- 1.96 SD
If probability = 0.99, exact values are mean +/- 2.576 SD
NOTE: Probabilities usually written as fractions, not percentages.
Make inferences about population based on data from sample.
The purpose of a sample is to give us information about a larger population . The process of drawing
conclusions about a population on the basis of sample data is called statistical inference.
Different samples from same population will vary. Statistics calculated from different samples will vary.
Question: is it different from the population or is it just due to chance?
Sampling distribution:
Is you selected many samples from the same population, you could calculate the mean for each
sample.
Could draw a histogram of the sample means - an idealised model of the histogram is called
the sampling distribution of the mean.
Central Limit Theorem: when n is large, the sampling distribution of the sample mean x-bar is
approximately Normal: x-bar is approximately N (μ, σ / n)
Therefore smaller n = smaller standard error
Standard error of the mean
In theory, you can calculate:
The mean of the sample means - should be a good estimate of population mean
The standard deviation of sample means - summarises variation between samples - called the
standard error of the mean, SE(mean)
In practice you have just one sample, you can calculate:
Sample mean and SE (mean) from the sample data
If s is the sample standard deviation and n is the sample size, then
Sample statistic numerical characteristic of a sample, e.g. sample mean calculated from sample data
Population parameter numerical characteristic of a population, e.g. population mean usually
unknown
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Document Summary

Writing hand: lurking variable therefore eliminated all left handed participants. 68% between 25. 1 and 34. 9 kg (mean 1 std dev = 30. 012 4. 864) Reference or "normal" range: values corresponding to 95% limits are sometimes called the reference range. Right grip strength females: 95% between 20. 3 and 39. 7 kg. Chance of a female in this age group having right grip strength outside this range (i. e. , <20. 3 or > 39. 7) is less than 5% or probability (p)< 0. 05, (or p<0. 025 for each tail separately). Where an individual is expected to sit, used in diagnostics. Doesn"t necessarily mean that those with a grip strength outside normal range are unwell: note: 1, 2 and 3 standard deviations are approximations, exact values can be obtained from tables, calculators or using statistical software. R commander: mean 0, sd 1 and values 0. 025 and 0. 975 for 95% If probability = 0. 95, exact values are mean +/- 1. 96 sd.

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