BIOL3090 Lecture Notes - Lecture 21: Eif4E, Eukaryotic Initiation Factor 3, Eif2
7 Aug 2018
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Document Summary
Transcription factories several genes transcribed at rnapii transcription factory. Contains capping, splicing and polyadenylation enzymes/factors in a cluster. Used to transcribe genes involved in similar processes. Not sure if cluster brings them together or they just are. Not all rnas they get transcribed get translated. Contains tandem repeats which fold up to form stem loop structures stretching across firre transcript has the capacity to interact with hnrnps which interact with dna. At least three loci on different chromosomes . Bare recruited to the transcription site of firre, and it is structural to hold things together. Having a cap binding protein can also enhance polyadenylation. Insulin dimerises and causes tyrosine phosphorylation which leads to amplifcation of the signal. A binding protein is bound to eif4e preventing it from having a role in translation. When they gets phosphorylated it releases eif4e allowing for translation. Binds gtp and recruits trna comes in and finds 40s subunit binds.
