MEDI113 Lecture Notes - Lecture 4: Rate Limiting, Pyruvate Dehydrogenase, Cardiac Muscle
23 Aug 2018
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Document Summary
Metabolism of carbohydrate: glycolysis, krebs cycle, electron transport chain. The only currency the body deals with. Hydrolysis of the terminal phosphate bond releases energy. Atp + h2o adp + pi + energy for work + heat. First law of thermodynamics: energy can neither be created or destroyed, almost all energy acquired from food, energy inputs = energy outputs, energy output = energy stored and heat, +ve energy balance = gain in energy storage. Ve energy balance = decline in energy storage. Second law: atp is a means of trapping energy, store energy from energy release reactions, adp can accept energy from compounds that are higher in free energy, phosphocreatine. Atp is a means of releasing energy: release energy to drive other chemical reactions, atp can release energy to form compounds that are lower on the free energy scale. Time from rest to muscle contraction: only 30 minutes. Atp: rest: atp utilisation: 0. 01 umol/g/s, exercise: atp utilisation: 10 umol/g/s.
