ECON1020 Lecture Notes - Heterotrimeric G Protein, Endoplasmic Reticulum, Phospholipase C
Document Summary
Effective way to shut off pka signaling? a. Gpcr --> heterotrimeric g protein --> activates phospholipase c i. 1: opens ip3-gated ca2+ channels on the endoplasmic. Must be rapidly generated and removed by the cell. Dag keeps pkc anchored at the inside of the cell membrane. Rate of diffusion for 2nd messengers varies a. Not about the increase in 2nd messenger, it"s about the i: many proteins that regulate ca2+ concentration iii. Ca2+ stays in a localized area, calbindin prevents ca2+ Different phospholipases a. signaling molecules: glycerol + 2 fatty acid chains. Ip3 activates ip3-gated ca2+ channel on endoplasmic reticulum. Glycerol + inositol + phosphate + 2 fatty acyl chains. Phosphates are add to any of the positions on the inositol sugar. Cleaves the phospholipids at other positions to create other. Shutting off the plc signaling pathway a. b. Pumped into the er or out into the ecm i: mitochondria takes it up --> er.
