EXSS1029 Lecture Notes - Lecture 10: Sirolimus, Glycogen, Leucine

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Measured using process where muscle supplied with amino acids and a stable isotope and then synthesis of the new proteins is assessed using biopsy. Following a single session of high resistance training (in the 24 hours after) After exercise: rate of synthesis increases peaks around 4-6 hours after declines 18-24 hours after. Goal of resistance training is to increase rate of muscle protein synthesis (single session = 0. 5% increase in muscle protein mass) Increase in muscle protein mass = increased rate of muscle protein breakdown. Increases protein synthesis (contractile proteins eg. z disc, m line proteins) Increased caused by mechanical stress - force (adaptation) Trigger mtor pathway with 2 types of stimulus = bigger response (eg. nutritional) Stimulus of mechanical force changed to chemical signal which causes a response (protein synthesis) When loaded with force = results in a chemical signal. Part of mt is an enzyme > binds with catalytic site although is blocked.

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