EXSS2022 Lecture Notes - Lecture 5: Lactic Acidosis, Endoplasmic Reticulum, Neuromuscular Junction

• School: University of Sydney
• Department: Exercise and Sport Science
• Course: EXSS2022
• Professor: Chin Moi Chow

Document Summary

Fatigue: failure to maintain required power output (reversible with rest) Psychological/neurophysiological factors affect neural drive to the muscles. Performance regulated in brain - ensure homeostasis maintained under stressful activity while also maintaining performance. Cns dictates the level of activity - by altering number of activated mu (pacing - feed forward) As activity goes on > rpe/discomfort increases > decrease activity to inhibit mu activation. Evidence: setchenov phenomenon - optimal period of rest - active recovery with diversion = recharged afferent nerve activity, reduce inhibition - shout, grunt, shot fired. Measurement of central fatigue: measure mvc and compare to non voluntary contraction (via electrical stimulation bypasses. Generation of force is decreased (protective), total non voluntary force is unaffected. Lactic acidosis - fall in ph in muscles > not necessarily due to lactate accumulation. Muscle acidosis likely caused by non mitochondrial atp turnover (aerobic metabolism)