EXSS2028 Lecture Notes - Lecture 6: Malonyl-Coa, Carnitine, Mitochondrial Matrix

• School: University of Sydney
• Department: Exercise and Sport Science
• Course: EXSS2028
• Professor: Kieron Rooney

Document Summary

Accumulation of amp = signal of decreasing energy status. Regulates glycolysis through effect on pfk (allosteric - changes shape depending on environment) Allosteric sit -point where molecule binds - determines whether opens or closed. Ampk is inactive with no phosphate attached. > amp binds to it > activation x10. > ampk stimulates ampkk and is activated (phosphate attached) > activation (most active state) As160 (moves glut4 glucose transporters to the membrane) Hsl (lipolysis - stimulates breakdown of triglycerides) Acc2 (converts acetyl coa and malonyl coa) Decreases with an increase in exercise intensity. Because of reduced fatty acid uptake into the mitochondria. Acts as a surrogate for the coa molecule. Tales fatty acid from cytosol and carnitine from imm. > fa has carnitine attached > can enter the mitochondrial membrane. Fa/coa enters matrix through cpt (becomes fatty acid coa > creates acetyl coa) Pyruvate also converted to acetyl coa - ready source of free coa.