EXSS2028 Lecture Notes - Lecture 9: Carbonic Anhydrase, Hemoglobin, Globular Protein
4 Sep 2018
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Shifting the curve to the right - reduced affinity. = increased po2 (dissolved oxygen) > more oxygen available for muscle consumption. Shifting the curve to the left - increased affinity. Dissolved oxygen is the oxygen available to your muscles. Anaemia - too few rbc or too little haemoglobin. Blocked circulation - blood cant come back to lungs - no oxygenation. Responsible for carrying o2 and transferring it directly to the mitochondria. Transported in the dissolved form by haemoglobin and proteins. In the form of bicarbonate (70%) - can serve as a buffer system. Co2 comes from metabolism, muscle cells, tissue. > travels into the plasma and enters rbcs. > carbonic anhydrase in the rbc catalyses the hydration of co2 (adds water) > dissociates into bicarbonate ions and hydrogen ions. Bicarbonate leaves cell due to electrical imbalance (gradient) more negatively charged ions in plasma. Hydrogen ions build up in the cell during exercise - cleaned up by build up of bicarbonate.
