EXSS2028 Lecture Notes - Lecture 2: Pyruvate Dehydrogenase, Oxidative Phosphorylation, Isomerase

• School: University of Sydney
• Department: Exercise and Sport Science
• Course: EXSS2028
• Professor: Kieron Rooney

Document Summary

Occurs in cytosol (aqueous component of cytoplasm) Glucose breaks down and converts to 2 pyruvate. No release of carbons (no co2) still 6 carbons. Phosphorylating the glucose molecule (adding energy: glucose molecule is phosphorylated = glucose-6-phosphate via hexokinase. Glucose-6-phopshate cant be converted back to glucose in muscle: glucose-6-phosphate produced from blood glucose or carbohydrate storage, equilibrium reaction > glucose-6-phosphate converted to fructose via isomerase. Isomerase changes the shape of glucose-6-phosphate = fructose-6-phosphate. Fructose and glucose-6-phosphate are interchangeable (convert to each other: another phosphate added - via pfk (phosphofructokinase) = fructose-1. 6-biphosphate. (cid:858)(cid:272)o(cid:373)(cid:373)itted step(cid:859) - cant be converted back. Harvesting phase - producing energy: fructose-1. 6-bisphosphate is split > produces 2 similar molecules - both 3 carbons and 1 phosphate in diff arrangements. + dhap: dhap converted to glyceraldehyde-3-phosphate (via isomerase) - during exercise and high energy demand, glyceraldehyde-3-phosphate converted to biphosphoglycerate via dehydrogenase nadh (added a phosphate)