EXSS3024 Lecture Notes - Lecture 5: Tidal Volume, Salbutamol, Weight Gain

• School: University of Sydney
• Department: Exercise and Sport Science
• Course: EXSS3024
• Professor: Daniel Hackett

Document Summary

Definitions: asthma = (cid:498)panting(cid:499, obstructive condition (like copd, chronic inflammatory disorder of airways where many cells play a role, in particular mast cells, eosinophils & t lymphocytes, mast cells increased from inflammation of airways. Inflammation causes recurrent episodes of wheezing, sob, chest tightness & coughing (at night/early morning: symptoms associated with variable airflow limitation which is partly reversible (spontaneously or with treatment, reversibility dependent on history of airflow asthma & medications used. Pathology & pathophysiology: normal = when exercising the airways dilate to increase airflow into lungs, asthma = narrowing of airways, shortening of smooth muscle which decreases cross section, thick mucous in airways. Example: asthma reaction after exposure to allergen: activate cells bearing allergen specific ige, inflammatory response to stimuli, early phase, recruit mast cells & macrophages . Tidal volume: amount of air inhaled or exhaled with each breath ( ~ 500 ml under resting conditions).