HSBH3014 Lecture Notes - Lecture 9: Shift Work, Sleep Disorder, Sleep Deprivation

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Biological clock: entrains and aligns the behaviorual, physiological processes and molecular pathways (internal synchronisation, under genetic control, adjustable, sensitive to light (1 zeitgeber) - environmental and artificial (blue light is ok) Circadian rhythm: (cid:498)endogenous(cid:499) (naturally occurring) with a pace maker found in the suprachiasmatic nucleus (scn: associated with a solar day: earth rotates around the sun, principal environmental synchronizer: light. When temp is nadir, you are the least alert. Endogenous rhythms: rhythms peaking in the afternoon, core temp, urinary electrolyte excretion, rhythms peaking in the morning, airway resistance, rhythms dipping in the morning, hr (lowest in morning, resting vo2. Core body temperature & alertness: the 2 rhythms coincide when they are at their peak & their lowest, amplitude becomes lower when alertness becomes lower. When the body clock is no longer in sync with the environment, such as people with shiftwork, pilots, nurses.

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