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Class Notes for PHAR2821 at University of Sydney

Drug Discovery and Design B

PHAR2821 Lecture Notes - Lecture 2: Optical Rotation
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*** in quiz*** Mesohasno optical rotation.

Pharmacy
PHAR2821
ANY
PHAR2821 Lecture Notes - Lecture 3: Cholinergic, Neurotransmission, Conotoxin
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Drug Discovery 3 24818 Cholinergicsmediate their effect via receptors stimulated byACh NAChR Architecture Pentameric ligand gatedion channels E.g.Curare, paralysed but fully awake E.g.alphabungarotoxin Conotoxin Ciga...

Pharmacy
PHAR2821
ANY
PHAR2821 Lecture Notes - Lecture 2: Alkane Stereochemistry, Butane
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Stereoisomers Diastereoisomers Geometricisomers Geometric isomers(duetorestricted rotationabout C=C)arealsoDiastereoisomers Named ascistrans(each Cmusthavethesamesubstituent attached)orEZ (uses CIP system) Cis the ident...

Pharmacy
PHAR2821
ANY
PHAR2821 Lecture Notes - Lecture 1: Physical Chemistry, Protein Structure, Cell Nucleus
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Drug Discovery 1 21818 Macromolecules as drug targets The beginning of modern pharmacy What dodrugsinteractwith? Drugsarechemicalsthatinteract withother chemicals Common classes of drugtargets: lipids Carbohydrates Nucle...

Pharmacy
PHAR2821
ANY
PHAR2821 Lecture Notes - Lecture 1: Racemic Mixture, Stereocenter, Optical Rotation
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Stereochemistry 31718 Structural isomersand stereoisomers(enantiomersand diasteroisomers) Isomers:different compoundswith same molecular formula STRUCTURAL ISOMERS: (Isomerswhose atomshave different connectivity) 1. Functi...

Pharmacy
PHAR2821
ANY
PHAR2821 Lecture 1: Drug Discovery 1C
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(realistic) formsunlesswe have prior knowledgefrome.g.pharmacophoremodels Docking The docking processaswe normally think ofit isatwostepprocessthatinvolves: Docking place the ligand in thebindingcavity Predict thebinding ...

Pharmacy
PHAR2821
ANY
PHAR2821 Lecture Notes - Lecture 1: National Institutes Of Health, Pharmacokinetics
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PK and PD PK:body does to drug PD:drug does to the body Often the tightestbottleneck in drugdiscovery Thisprocessideally requires the simultaneousoptimisationofmultipleparametersand isthusa time consuming and costly st...

Pharmacy
PHAR2821
ANY
PHAR2821 Lecture Notes - Lecture 2: Pharmacokinetics, Pharmacodynamics, Natural Product
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TARGET VALIDATION Involvesdemonstratingthe relevanceofthetarget proteininadisease processpathogenicity and ideallyrequiresbothgainand lossoffunctionstudies Thisisaccomplished primarilywithknock out orknock inanimalmodels...

Pharmacy
PHAR2821
ANY
PHAR2821 Lecture Notes - Lecture 3: Microorganism, Hoffmann-La Roche, Pharmaceutical Industry
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Aspects of Drug Design 17818 Research based pharmaceuticalcompaniesspend about 20oftheir salesonresearch and development Thisissignificantly higher thaninmost other industries Since 1980US pharma companieshavedoubledspe...

Pharmacy
PHAR2821
ANY

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