PHAR3816 Lecture Notes - Lecture 19: Iron-Deficiency Anemia, Hematocrit, Colony-Stimulating Factor
22 Jul 2018
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Document Summary
Blood - cellular components (rbc, wbc, plt) & plasma. Cellular components of blood are derived from pluripotent stem cells in bone marrow (e. g. vertebrae, sternum, ribs, long bones - in children) Stem cells undergo differentiation in a process called hematopoiesis, which is stimulated by haematopoietins or colony stimulating factors (gm-csf, g-csf, erythropoietin, thrombopoietin) Produced in bone marrow by process of erythropoiesis, controlled by the hormone erythropoietin which is produced mainly in the kidneys: haemoglobin in the erythrocyte provides oxygen transport mechanism of the blood. Give recombinant human erythropoietin for anaemia associated with ckd. Elevated: dehydration, chronic respiratory diseases, living at high altitudes, polycythemia vera (overproduction of rbc: decreased: hemorrhage, anaemia (fe, b12, folate deficiencies; increased destruction or decreased production), leukemia, multiple myeloma. Macrocytosis e. g. b12 & folic acid, liver disease, alcohol excess. Average weight of haemoglobin contained in red cell. Increased in macrocytic anaemias; decreased in microcytic anaemias. Average concentration of haemoglobin in 100ml of red cells.
