PHAR3816 Lecture Notes - Lecture 14: Ace Inhibitor, Vascular Resistance, Central Venous Pressure
22 Jul 2018
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Document Summary
An increase in age increases bp and the risk of atherosclerosis and cvd. It is lower in women before menopause compared to men and those with genetic mutation such as diabetes that are inherited have an increased risk. Very common (e. g. ~ 50 million us: more prevalent in males (vs. females) and blacks (vs. caucasians) Incidence increases with age, onset usually with 3rd- Blood pressure is proportional to blood flow (cardiac output) blood volume, overall compliance (elasticity of blood vessels) and peripheral vascular resistance (resistance to passage of blood through arteries: dyslipidaemia. Raised blood pressure: diabetes mellitus, obesity, dietary factors. In normal and hypertensive patients, blood pressure is regulated at 4 sites: resistance in arterioles (from the heart, capacity in venules (to the heart, pump (heart, kidney: regulates the volume of intravascular fluid. Blood pressure in hypertensive patients is regulated by the same mechanisms as in normal, but renal blood volume-pressure control system is set at high".
