PHAR3816 Lecture Notes - Lecture 2: Coronary Artery Disease, Angina Pectoris, Peripheral Artery Disease
23 Jul 2018
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Document Summary
Lipid deposits build up on the inner walls of arteries = reduced lumen. This results in reduced blood flow and ultimately, clogging of arteries. Blood flow arrest leads to heart attach and/or stroke. Plasma with lipid-rich problems causes frothing which increases risk of atherosclerosis. Lipid-rich diet can increase blood lipids (cholesterol and triglycerides). Lipids accumulate in the arteries and reduce blood flow. Cell recognition and signaling (each cell has a different set of lipids and look different on outside) Fatty acids (n>100) mainly in triglycerides, p-lipids: only small amounts of free fatty acids (free fatty acids are toxic and very little in body) C14-c22, c16-c18 most common: mostly unsaturated, double bond generally between c9-c10. Essential fatty acids (efas): cannot be synthesized, available through diet. e. g. cis-linoleic acid (la; makes up 10-20% of fatty acids in triglycerides, p-lipids, alpha-linolenic acid (ala) Need to compartmentalize fatty acids or free fatty acid forms causing toxicity.
