PHAR3817 Lecture Notes - Lecture 2: Acetylcholinesterase, Adenylyl Cyclase, Ciliary Muscle
22 Jul 2018
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Document Summary
Autonomic nervous system (ans) = involuntary control over the contraction of smooth muscle, cardiac muscle and glandular activity. Cholinergics - mediate their effect via receptors stimulated by acetylcholine (ach) Adrenergic - medicate their effect via receptors stimulated by epinephrine/norepinephrine. It is most abundant in diets with high protein content. There are two types of cholinergic receptors: muscarinic receptors g-protein coupled receptor (7tm, nicotinic receptor. Inhibit adenyl cyclase activity reduce camp orthosteric site on gpcr, which leads to the activation of multiple signalling pathways balanced between the g proteins, - arrestins (help terminate response from cells) and/or other signalling effectors. Signalling occurs following the binding of endogenous hormones to the. Stimulates secretion in stomach, stimulates movement, inhibit sphincter closing. Acetylcholine is an endogenous transmitter but it is not a great drug because: Lacks selectivity hits both nicotinic and muscarinic receptors. Permanent positive charge poor absorption across lipid membrane. Poor stability undergoes both acid and base catalyzed hydrolysis.
