PHAR3817 Lecture Notes - Lecture 8: Obstructive Lung Disease, Restrictive Lung Disease, Ayurveda
22 Jul 2018
School
Department
Course
Professor
Document Summary
Inhaler technique: origins of inhalation therapy for respiratory condition may lie in traditional ayurvedic medicine in india about 4000 years ago, medicines grounds into powers and pastes and then ignited. Inhaler" -> phrase coined in 1778 by dr john mudge -> used to describe a system involving a pewter tankard which opium vapour was inhaled to treat cough. Upper airways: warm, humidify (>99% rh, filter air prior to its arrival in the lungs. Portal of entry to the body: drugs on airway surfaces-> blood stream-> organs. Alternative to other drug delivery methods e. g. injection -> fast onset analgesics, peptides and proteins. Respiration = oxygenating the blood and removing co2. Anatomic dead space: gas fails to reach alveoli, unavailable for gas exchange, patients asked to exhale fully. Cilia -> beat at 15hz, about 200 cilia per ciliated cell, few microns in length. Propels mucous towards the larynx, swallowed or expectorated. Less and less mucous further down the airways.
