PHAR3818 Lecture Notes - Lecture 10: Thyroxine-Binding Globulin, Thyroid Peroxidase, Autoimmune Thyroiditis

• School: University of Sydney
• Department: Pharmacy
• Course: PHAR3818
• Professor: Philip Kwok

Document Summary

Glossary: hypothyroidism thyroid hormone deficiency, hashimotos thyroiditis autoimmune hypothyroidism. Thyrotoxicosis overproduction of thyroid hormones t3,t4: hyperthyroidism the result of excessive thyroid function e. g. graves disease. Graves disease most common type of thyrotoxicosis. Tpoab thyroid peroxidase antibody predictor of hyperthyroidism. Euthyroid normal range, normal function when on appropriate treatment. T3 triiodothyronine (liothyronine: maintain thermogenic and metabolic homeostasis. Iodide is converted to thyroid hormones in 4 phases. Oxidation of iodide to iodine & incorporation of tyrosine (mit (mono iodo tyrosine), dit (di))- joined/coupled. Coupling of iodinated tyrosine residues to form thyroid hormones (mit+dit t3; dit+dit t4) Hypothalamus, anterior pituitary, thyroid gland and amount of circulating hormone. Peripheral actions released via thyroid gland adequate hormones (t4, T3), negative message sent back to hypothalamus and anterior pituitary to stop secretion of trh and tsh. If there is inadequate amount, message sent back to hypothalamus to secrete trh and tsh. Takes 4-8 weeks to calibrate e. g. oroxine dose inadequate, give negative feed.