PHAR3818 Lecture Notes - Lecture 15: Hormonal Contraception, Combined Oral Contraceptive Pill, Emergency Contraception
23 Jul 2018
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Document Summary
Barrier methods- mal e and female: hormonal methods: combined and progestogen only. 70% of women of reproductive age use a contraception method but >50% of women have had an unplanned pregnancy. Combination oral contraceptive pill (cocp: monophasic - same dose for 21 days + 7 inactive pills, multiphasic. Triphasic - varied dose of e/p across the 21 day + 7 inactive pills. Newer multiphasic (qlaira) 26 days active with varying e/p, 2 days inactive: vaginal ring - nuvaring. Suppresses mid-cycle peaks of lh and fsh (blocks ovulation) Thickens cervical mucus (impermeable: decreases sperm motility. Prevents development of dominant follicle in the follicular progression. Always used in combination for protective effect of progestogen on oestrogen. Nausea, vomiting, breast tenderness, fluid retention, change in libido. Hdl, vldl, triglycerides, coagulation factors, ldl, bone resorption. Thromboembolic disorder, uterine bleeding, liver disease, cerebrovascular artery disease, coronary artery disease, breast cancer. The higher the oestrogen, the higher the risk of vte.
