PHAR3819 Lecture Notes - Lecture 11: Carbohydrate Metabolism, Lipid Metabolism, Bilirubin
23 Jul 2018
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Document Summary
A 43-year-old man is admitted to hospital suffering from occasional vomiting, jaundice and hallucinations. Laboratory tests: elevated bilirubin concentration, elevated ast activity, and low albumin concentration, inr 2. 5. Clinical signs: generalised itching and yellowish colour to skin and eyes, fever and upper quadrant pain, signs of bruising and dark coloured urine. Amino acid metabolism: de-toxification, waste product removal. Plasma protein synthesis e. g. clotting factors (synthesised in liver), albumin: Removal /storage of toxins: blood filtration: removal or bacteria and other particulate matter. Blood filtration, removal of bacteria and other particulate matter. There is no single or simple test of overall hepatic function: Liver enzyme concentrations in blood: human serum albumin concentration. Breakdown product of haemoglobin from worn red blood cells: heme + globin, heme converted to bilirubin, which is carried to liver, where it is conjugated with glucuronides, and excreted. Can be measured in the unconjugated (indirect) or conjugated (direct) form. Increased direct bilirubin: haemolytic anaemia, haemolytic disease of the newborn.
