PCOL2605 Lecture Notes - Lecture 1: Muscarinic Acetylcholine Receptor M1, Nicotinic Acetylcholine Receptor, Skeletal Muscle
23 Oct 2018
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Mechanism of drug action and drug receptors 1 - pharmacodynamics. Drugs achieve their therapeutic effects by acting primarily on either **exam q** Proteins found on the surface of cell membranes, or inside the cell. They are binding sites for chemicals which are produced naturally in the body. Nicotinic receptors (stimulation of ganglion cells and contraction of skeletal muscle), communication between 2 nerves. Mus(cid:272)a(cid:396)i(cid:374)i(cid:272) (cid:396)e(cid:272)epto(cid:396)s, do(cid:374)"t (cid:374)eed (cid:395)ui(cid:272)k (cid:396)espo(cid:374)se, s(cid:373)ooth (cid:373)us(cid:272)le. ((cid:373)1 receptor gastric acid secretion; m2 bradycardia (slows heart)ppop; m3 smooth muscle contraction) Beta adrenoceptors (beta 1 cardiac stimulation; beta2 bronchodilation) H1 (vasodilation, itch, smooth muscle contraction contraction of airways) Atii type 1 (at1 vasoconstriction, increase bp) An agonist thus exhibits affinity and efficacy (intrinsic activity: bonds are usually relatively weak and easily reversible. Usually consists of ionic bonds, hydrogen binding and van der waals forces. 100% of the receptors economising, using less neurotransmitter for a maximal response.
