PCOL2605 Lecture Notes - Lecture 22: Aluminium Hydroxide, Peptic Ulcer, Osteoporosis
23 Oct 2018
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Parietal cells secrete a proton into the lumen of the stomach in exchange for a k+ Chloride ions passively flow out through the cl- channels in to the lumen to maintain electroneutrality. Histamine: released from enterochromaffin like cells acts on h2 receptors to stimulate acid release. Gastrin: released from g cells in the gastric glands stimulates acid secretion by stimulating histamine release from ecl. Acetylcholine: released from parasympathetic post ganglionic nerve fibres stimulates histamine release and also stimulates parietal cells. Reflux disease is common and can lead to a significant impairment of well being or quality of life. Barrett"s oesophagus changes to cells as bottom of oesophagus. Histamine h2 receptor blocking agents ranitidine etc, competitive antagonisits that turn off parietal cells. Competitive antagonists of histamine at histamine h2 receptors. By inhibiting the action of histamine at h2 receptors on the parietal cell they reduce the secretion of gastric acid. Used in the treatment of gastric and duodenal ulcers.
