PCOL2605 Lecture 3: NSAIDS
23 Oct 2018
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Explain how acetyl salicylic acid was developed from a traditional medicine. Explain irreversible mechanism of acetyl salicylic acid and how this results inhibition of platelet aggregation. Explain the mechanism of action common to other nonsteroidal antiinflammatory drugs (nsaids) Describe the binding site of acetyl salicylic acid as well as other nsaids. Ad30, aulus cornelius celsus - boiled vinegar extract of willow leaves for relief of pain from prolapsed uterus and other conditions. Caius plinus secundus (ad 23 79) - poplar bark infusions for pain in sciatica and poultices made from vinegar-soaked poplar bark for the treatment of gout. Dioscorides (ad 60) materica medica - boiled aqueous extract of willow leaves or ash of willow bark could be used for treating corns, skin diseases, gout and earache. Galen (ad 2) - antiseptic properties of willow leaves for the treatment of various skin conditions such as wounds and ulcers.
