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Class Notes for PCOL3011 at University of Sydney

Toxicology

PCOL3011 Lecture Notes - Lecture 23: Disulfide, Conotoxin, Neuromuscular Junction

Cone snail toxins: Lecture 24 Cone snails are widely dispersed, mainly tropical The environmental machinery: Species and predatory diversity: (100s of species) Evolved venoms for prey captur...

Pharmacology
PCOL3011
Slade
PCOL3011 Lecture Notes - Lecture 18: Dorsal Root Ganglion, Abdominal Pain, Microtubule

Neurotoxicology 1: What is Neurotoxicology? Study of toxins that target neurons These neurons could be o In the brain o In the peripheral nervous system o Cell body in the CN...

Pharmacology
PCOL3011
Slade
PCOL3011 Lecture Notes - Lecture 19: Memantine, Xerostomia, Mescaline

Neurotoxicity 2: Lead Toxicity Lead readily crosses BBB Lead produces a variable response in humans. Toxic to many organs of the body, including nervous system, heart, lungs, bone, reproductive ...

Pharmacology
PCOL3011
Slade
PCOL3011 Lecture Notes - Lecture 17: Ferritin, Bile Acid, Lipid Peroxidation

Liver toxicology: Toxicology Lecture 17 Liver as a target organ: Susceptibility of the liver: Uniquely susceptible because of: o Anatomy High blood flow, unusual c...

Pharmacology
PCOL3011
Slade
PCOL3011 Lecture Notes - Lecture 15: Asbestosis, Acute Respiratory Distress Syndrome, Macrophage

Kidney toxicity Lecture 15 Respiratory system as target organ: In contact with external environment Samples a large volume of air o >10,000 L per day o Exposed t...

Pharmacology
PCOL3011
Slade
PCOL3011 Lecture Notes - Lecture 20: Dna Mismatch Repair, P53, Antibiotics

Causes of cancer Normal tissue development: Sequential 'commitment' of 'cells 'to 'specialised tasks Genetic/epigenetic mechanism control organogenesis Limited alteration in gene sequences after fertil...

Pharmacology
PCOL3011
Slade
PCOL3011 Lecture Notes - Lecture 21: Haber Process, Methotrexate, Fritz Haber

Chemotherapy: Lecture 21 1. Is chemotherapy all about cancer? 2. Role of cell cycle? 3. Dosing rationale 4. Pharmacology of osme agents What is chemotherapy? o Includes antibiotics and c...

Pharmacology
PCOL3011
Slade
PCOL3011 Lecture Notes - Lecture 16: Cytosol, Likelihood Ratios In Diagnostic Testing, Renal Function

Kidney Toxicity Lecture 16 FDA: A biomarker is a defined characteristic that is measured as an indicator of normal biological processes, pathogenic processes, or responses to an exposure or intervention, including therapeu...

Pharmacology
PCOL3011
Slade
PCOL3011 Lecture Notes - Lecture 14: Sarcoma, Small Interfering Rna, Oxidative Stress

Toxicology of Nanoparticles Lecture 14 Nanomaterials and nanoparticles: Nano, from the Greek nanos meaning dwarf Nanomaterials: materials with structural components having one dimension less than 1 m Nanoparticles: part...

Pharmacology
PCOL3011
Slade
PCOL3011 Lecture Notes - Lecture 13: Respiratory Rate, Blood Pressure, Allometry

Non-clinical toxicology (non-human) Lecture 13 Why do these experiments? History teaches us E.g. sulphanilamide that lead to American law changes o Corporate responsibility: Dr. Samual Evans Masse...

Pharmacology
PCOL3011
Slade
PCOL3011 Lecture Notes - Lecture 10: Carcinoma, Polycyclic Aromatic Hydrocarbon, Genotoxicity

Toxicology Lecture 9 Thresholds and Risk Toxicological Cost-benefit analysis What is risk? Poorly defined Usually poorly understood in quantitative terms Mathematical probability t...

Pharmacology
PCOL3011
Slade
PCOL3011 Lecture Notes - Lecture 9: Evidence-Based Medicine, Active Transport, Eddleston

Toxicology Lecture 9 Pesticide Toxicology Pesticides and Suicide (A neglected tropical disease?) World health organisation 2006: Pesticide poisoning is the single most important global means of suicide ...

Pharmacology
PCOL3011
Slade
PCOL3011 Lecture Notes - Lecture 8: Noh, Weighted Arithmetic Mean, Melanoma

Toxicology Lecture 8 Mortality and Morbidity Statistics Mortality statistics What they are How they are collected Reliability- confounding Manipulation of mortality statistics Crude rates ...

Pharmacology
PCOL3011
Slade
PCOL3011 Lecture Notes - Lecture 7: Entomology, Cardiac Glycoside, Titration

Analysing Dose-response Data Two types of dose response curve 1. Graded E.g. single organ Guinea pig ileum response to Ach 2. Quantal (discrete) Populations E.g. lethality curves (LD50) ...

Pharmacology
PCOL3011
Slade
PCOL3011 Lecture Notes - Lecture 6: Polypharmacy, Toxicokinetics, Comorbidity

Drug toxicity in older people What is drug toxicity? Any noxious, unintended and undesired effect of a drug, excluding therapeutic failures, intentional and accidental poisoning and drug abuse Serious ADR: ...

Pharmacology
PCOL3011
Slade

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