PCOL3011 Lecture Notes - Lecture 20: Dna Mismatch Repair, P53, Antibiotics
Document Summary
Normal tissue development: sequential "commitment" of "cells "to "specialised tasks, genetic/epigenetic mechanism control organogenesis, limited alteration in gene sequences after fertilization, except t/b lymphocyte clonal expansion, constant renewal in some cell populations epithelia, static in others nerves. What is cancer: cancer: unrestricted growth of tissue, benign or malignant, most are epithelial-derived, sarcoma- connective tissue, lymphoma- lymphatic tissue, leukaemia- hematological derived, tumours are not made up of only one cell type. 1775: percival pott & john hill identified link between soot and cancer in chimney sweeps. Next 100 years: links between cancer and paraffin, arsenic, radium paint, aniline dyes, pitch, tar. 1915: katsusabouro yamagiwa & koichi ichkawa showed experimental proof that coal caused skin cancer in rabbits. 1930: ernest kennaway"s team identified polycyclic aromatic hydrocarbons were carcinogenic compound in coal/soot/tar (mainly benzo (a) pyrene) Experimental studies designed to predict carcinogenic potential of all drugs.
