PCOL3011 Lecture Notes - Lecture 18: Dorsal Root Ganglion, Abdominal Pain, Microtubule

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25 Aug 2018
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How do toxins get into the brain: chemicals or drugs are taken or otherwise gain access to the blood stream, not all chemicals in the blood can penetrate the brain, blood brain barrier limits access to the brain. Regions of brain not enclosed by bbb: circumventricular organs, all these regions need to respond to factors present in the system circulation, blood/csf lower barrier than bbb, greater access for toxins. Why are neurons highly sensitive to toxins: neurons have a very different structure to other cells in the body. Morphology: neurons are long, complicated, transport substances over long distances (>1m)- atp dependent, need to make and deliver lots of proteins, long axon/dendrites also vulnerable to damage. Axonal transport: (because they are long: all areas of the neuron need proteins, peptides, neurotransmitters, active transport but if this system damaged the other end of the neuron is isolated, peripheral axons/terminals vulnerable to toxins.

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